The chewing brush,especially in Africa

Lætadianism—the religious revival as it appeared in Northern Norway in the second half of the last century—is analyzed as a form of symbolic opposition (Schwimmer 1972) from the Sámi and the Kvens against the Norwegian policy of cultural and economic integration. The expansion of Norwegian administration and economy from the middle of the 19th century, established new status‐sets and fields of interaction within agriculture, school‐system and health service. Events and interaction within each of these fields created circumstances for what took place in the actor's other relationship and this dynamic is thus analysed as implication systems (Grenhaug 1978).

All interaction with Norwegian society was built upon Norwegian statuses and values and the Sámi and Kvens established a new definition of the situation by reversing the Norwegian standards through the medium of Christianity. Their material poverty was converted into spiritual wealth and thus a different inter‐ethnic context of interaction surfaced. This new opportunity situation (Barth 1966) made it possible to reject the Norwegian society which earlier had rejected them.     

Prevention of Bacteriophage Adsorption to Staphylococcus aureus by Immunoglobulin G

Normal human and rabbit sera when incubated with Staphylococcus aureus inhibit the adsorption of bacteriophages. The bacteriophage adsorption was also inhibited by separated normal immunoglobulin M (IgM), F(ab')(2), and Fab-fragments of IgG. No inhibition was obtained with myeloma IgG or Fc-fragments of normal human and rabbit IgG. The results indicate that the serum inhibition of bacteriophage adsorption to S. aureus is not due to a binding of IgG to protein A on the surface of S. aureus.     

Esterase

Zusammenfassung Die Geschlechtsunterschiede der Nierenesterase der Maus wurden mit quantitativen, histochemischen und elektrophoretischen Methoden untersucht. Bei allen drei Methoden wurden Ester des 8-Hydroxichinolins eingesetzt.Die Nierenesterase der Maus läßt sich maximal in 19 bei pH 8.3 anodisch wandernde Banden auftrennen. Mindestens 6 dieser 19 Banden sind beim Männchen wesentlich stärker als beim Weibchen.Vergleichende Aktivitätsmessungen ergeben, daß das Verhältnis der Spaltgeschwindigkeit Butyrat/Acetat im Männchen viel höher liegt als im Weibchen. Daraus muß gefolgert werden, daß zumindest die Mehrzahl unter diesen 6 Banden Butyrate bevorzugt umsetzt. Aus den histochemischen Befunden ist zu entnehmen, daß die entsprechenden Esterasekomponenten vorwiegend oder ganz in den ersten beiden Dritteln der Hauptstücke (P₁ und P₂) lokalisiert sein müssen.Bei weiblichen Tieren dominiert die relativ langsam wandernde Bande IV 50. Sie spaltet Acetate relativ gut. Die Acetylester werden vergleichsweise schnell im letzten Drittel der Hauptstücke (P₃) umgesetzt. Möglicherweise ist die der Bande IV 50 entsprechende Esterase in P₃ lokalisiert.

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EsteraseXI. Histochemical, electrophoretic and quantitative observations on the sex-specific pattern of substrate cleavage by the nonspecific kidney esterase of mice

Summary The sex differences of the esterase in mouse kidney were investigated with quantitative, histochemical, and electrophoretic methods. In each of the three methods esters of 8-hydroxiquinoline were used. The kidney esterase of the mouse can be separated into 19 bands maximally, migrating at pH 8.3 towards the anode. At least 6 of these 19 bands are considerably stronger in the males than in the females. By comparative determination of the esterase activity it is shown that the ratio of substrate splitting butyrate/acetate is much higher in males than in females. Therefore it is concluded that at least the majority of these 6 bands have a tendency to split the butyrates especially well. The histochemical results show that the corresponding esterase components must be localized preferentially or totally in the first two thirds of the proximal tubules (P₁ and P₂).In the females the relatively slow moving band IV 50 is dominant. It splits acetates quite fast. The turnover of the acetyl esters is relatively rapid in the last third of the proximal tubules (P₃). Perhaps the esterase component corresponding to the band IV 50 is localized in P₃.

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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft (SFB 46).     

Specific binding of lactoferrin to Aeromonas hydrophila

The subunit S1 of pertussis toxin (PT) was purified as the recombinant product BacS1 from the culture supernatant of a Bacillus subtilis strain containing a secretion vector with a DNA fragment coding for the mature subunit S1 inserted downstream of the signal sequence of the alpha-amylase gene. The method of purification was successive ion exchange and adsorption chromatography. BacS1 occurred in two forms (28 and 20 kDa) of which the truncated 20-kDa peptide was the main one in the supernatant. The truncated BacS1 was purified and shown to have the same NH2-terminus as the full-size (28 kDa) BacS1. It was also enzymatically active indicating correct conformation. The truncated BacS1 was also shown to elicit neutralizing and protective antibodies when injected into mice or rabbits.     

Early supported discharge after stroke in Bergen (ESD Stroke Bergen): three and six months results of a randomised controlled trial comparing two early supported discharge schemes with treatment as usual

Background

Stroke causes lasting disability and the burden of stroke is expected to increase substantially during the next decades. Optimal rehabilitation is therefore mandatory. Early supported discharge (ESD) has previously shown beneficial, but all major studies were carried out more than ten years ago. We wanted to implement and study the results of ESD in our community today with comparisons between ESD and treatment as usual, as well as between two different ESD models.

Methods

Patients with acute stroke were included during a three year period (2008–11) in a randomised controlled study comparing two different ESD models to treatment as usual. The two ESD models differed by the location of treatment: either in a day unit or in the patients’ homes. Patients in the ESD groups were followed by a multi-disciplinary ambulatory team in the stroke unit and discharged home as early as possible. The ESD models also comprised treatment by a multi-disciplinary community health team for up to five weeks and follow-up controls after 3 and 6 months. Primary outcome was modified Rankin Scale (mRS) at six months.

Results

Three-hundred-and-six patients were included. mRS scores and change scores were non-significantly better in the two ESD groups at 3 and 6 months. Within-group improvement from baseline to 3 months was significant in the ESD 1 (p?=?0.042) and ESD 2 (p?=?0.001) groups, but not in the controls. More patients in the pooled ESD groups were independent at 3 (p?=?0.086) and 6 months (p?=?0.122) compared to controls and there also was a significant difference in 3 month change score between them (p?=?0.049). There were no differences between the two ESD groups. Length of stay in the stroke unit was 11 days in all groups.

Conclusions

Patients in the ESD groups tended to be more independent than controls at 3 and 6 months, but no clear statistically significant differences were found. The added effect of supported discharge and improved follow-up seems to be rather modest. The improved stroke treatment of today may necessitate larger patient samples to demonstrate additional benefit of ESD.

Clinical trial registration

Unique identifier: NCT00771771

     

Multiple mating and a low incidence of cuckoldry for nest-holding males in the two-spotted goby, Gobiusculus flavescens

Background  

A major question in behavioural ecology concerns the relationship between genetic mating systems and the strength of sexual selection. In this study, we investigated the genetic mating system of the two-spotted goby (Gobiusculus flavescens), a useful fish model for the study of sexual selection whose genetic mating system remains uncharacterized. We developed four polymorphic microsatellite markers and used them to conduct parentage analyses on 21 nests collected during the breeding season to examine the rates of multiple mating by males and to test for evidence of alternative mating strategies.     

European foulbrood in honey bees

European foulbrood (EFB) is a severe bacterial brood disease caused by the Gram-positive bacterium Melissocccus plutonius. The disease has a worldwide distribution and is an increasing problem in some areas. Although the causative agent of EFB was described almost a century ago, many basic aspects of its pathogenesis are still unknown. This review presents both historical results and recent molecular data to synthesize present knowledge of this enigmatic honey bee disease.     

Morningness propensity in young adults born prematurely: the Helsinki study of very low birth weight adults

The authors explored morningness-eveningness propensity in adults born prematurely at very low birth weight (VLBW; 相似文献   

Vitamin D Deficiency in Children with a Chronic Illness–Seasonal and Age-Related Variations in Serum 25-hydroxy Vitamin D Concentrations

Introduction

Children and adolescents with a chronic illness have potential risk factors for vitamin D deficiency. An optimal vitamin D status might have multiple health effects. This study evaluated vitamin D status and its association with age, gender, and season in a large cohort of chronically ill Finnish patients at a tertiary pediatric outpatient clinic. A cross-sectional register-based study was carried out, involving altogether 1351 children (51% boys, age range 0.2–18 years), who visited the outpatient clinic during 2007–2010 and had their vitamin D status (S-25-OHD) determined. A post-doc analysis was conducted to identify predisposing and preventing factors for vitamin D deficiency.

Results

Almost half (47%) of the S-25-OHD values were consistent with subnormal vitamin D status (S-25-OHD <50 nmol/L) while only 12% were >80 nmol/L. Age and season were the most important determinants for S-25-OHD concentration. Mean S-25-OHD concentration differed between age groups (Kruskal-Wallis; p<0.001), adolescents being at highest risk for vitamin D insufficiency. Young age and vitamin D supplementation were preventive factors for deficiency, while non-Finnish ethnic background was a predisposing factor. S-25-OHD showed significant seasonal variation in children older than 6 years. In the whole cohort, S-25-OHD was on average 13 nmol/L higher in summer than in winter, and the prevalence of vitamin D deficiency ( =  S-25-OHD <37.5 nmol/l) varied from 11% in summer to 29% in winter.

Conclusions

The finding that almost half of the studied Finnish children with a chronic illness had suboptimal vitamin D status is alarming. Inferior vitamin D status was noted in adolescents compared with younger children, suggesting that imbalance between intake and requirement evolves with age. Although less common during summer, subnormal vitamin D status was still observed in 28% of those evaluated in summer. Clinicians should identify individuals at risk and actively recommend vitamin D supplementation.